GABAB receptor antibodies in limbic encephalitis and anti-GAD-associated neurologic disorders
نویسندگان
چکیده
منابع مشابه
GABA(B) receptor antibodies in limbic encephalitis and anti-GAD-associated neurologic disorders.
BACKGROUND γ-Aminobutyric acid-B receptor antibodies (GABA(B)R-ab) were recently described in 15 patients with limbic encephalitis (LE), associated with small-cell lung cancer (SCLC) or with concurrent glutamic acid decarboxylase (GAD) antibodies. We analyzed the frequency of GABA(B)R-ab in 147 patients with LE or neurologic syndromes associated with GAD-ab. METHODS We examined the presence o...
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OBJECTIVE To report the clinical and immunological features of a novel autoantigen related to limbic encephalitis (LE) and the effect of patients' antibodies on neuronal cultures. METHODS We conducted clinical analyses of 10 patients with LE. Immunoprecipitation and mass spectrometry were used to identify the antigens. Human embryonic kidney 293 cells expressing the antigens were used in immu...
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INTRODUCTION Autoantibodies to the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor and N-methyl-d-aspartate (NMDA) receptor are known to be the causes of autoimmune encephalitis particularly limbic encephalitis. The involvement of the peripheral nervous system is rarely reported. METHODS We analyzed the serial nerve conduction studies of a previously reported case of ...
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INTRODUCTION Limbic encephalitis (LE) is characterised by seizures and impairment of short-term memory as well as behavioural and psychiatric symptoms such as anxiety, depression, personality change and hallucinations. Onset of these symptoms is typically subacute over a few weeks or months but may also evolve over a few days. In many patients, limbic encephalitis is a paraneoplastic syndrome u...
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Introduction Hu antibodies have previously been associated with longer survival of patients with small-cell lung cancer (SCLC). VGCC antibodies play a pathogenic role in the Lambert Eaton myasthenic syndrome (LEMS) which is also associated with SCLC, and these antibodies may reduce tumour growth. We tested a large cohort of sera from SCLC patients to see whether Hu and VGCC antibodies correlate...
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ژورنال
عنوان ژورنال: Neurology
سال: 2011
ISSN: 0028-3878,1526-632X
DOI: 10.1212/wnl.0b013e31820e7b8d